| Character | Actor |
|---|---|
| Ryan Stone | Sandra Bullock |
| Matt Kowalski | George Clooney |
| Mission Control (voice) | Ed Harris |
| Aningaaq (voice) | Orto Ignatiussen |
| Shariff (voice) | Phaldut Sharma |
| Explorer Captain (voice) | Amy Warren |
| Russian Space Station Captain (voice) | Basher Savage |